UK Lord Kelvin - Adam Smith PhD Scholarship in Stochastic Process Algebra Modelling, University of Glasgow
Stochastic process algebra modelling of ROS regulation in oxidative stress
Supervisor: Professor Muffy Calder
Recently, Professors Calder, in collaboration with Professor Hillston and Dr Gilmore (Edinburgh University) have developed a new approach to intracellular signalling modelling based on the idea that signalling pathways have stochastic, computational content; behaviour is modelled by stochastic process algebras (SPAs), which denote continuous time Markov chains.The SPA approach is novel, modelling species rather than molecules, and affords new quantitative analysis using logics or throughput, in addition to traditional differential equation (DE) simulations and stochastic simulation.
The aim of this studentship, in collaboration with Professor Dominiczak, Cardiovascular Medicine, is to develop the stochastic process algebra (SPA) approach for validated, predictive models of the regulation of ROS (reactive oxygen species)� in oxidative stress. Oxidative stress is a major factor in cardiovascular diseases and endothelial dysfunction in particular. The main problem is an imbalance between ROS (reactive oxygen species) and nitric oxide, the relationships between the components are complex, involving switching and feedbacks.
The student will extend the SPA approach to model spatial aspects and abstractions over pathway components, and build comprehensive models of oxidative stress, reflecting the subtle relationships between the ways ROS and nitric oxide are produced and consumed.
The starting point will be a small prototype model which has been developed by Calder, Hillston and Dominiczak.
The studentship is for four years.Further details are given at this page.
The studentship is suitable for candidates with a good first degree (or Masters) in Computing Science or Mathematics; a willingness to engage with medicine and biochemistry is also required. The student will also participate in several related collaborative research projects.
The closing date is 30 June 2007.
The application procedure can be found at:
http://www.dcs.gla.ac.uk/phd/ application.html.
Informal enquiries to: muffy@dcs.gla.ac.uk.
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